Environment variables can sometimes be a pain to deal with. Since environment variables are often cached or loaded only once, a change might not be immediately reflected in the application that we intend to apply them to.

In my case, I need to debug our ASP.NET application and need the new environment variables.

Restarting the Visual Studio itself was not enough. I tried to kill the worker process and that doesn't help either. At the end, I tried one thing that works which I got from a forum, i.e., enter the following command on command prompt or PowerShell run in admin mode:

iisreset